Ciclopirox 8% HPCH Nail Lacquer in the Treatment of Mild-to-Moderate Onychomycosis: A Randomized, Double-Blind Amorolfine Controlled Study Using a Blinded Evaluator
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چکیده
منابع مشابه
Ciclopirox 8% HPCH Nail Lacquer in the Treatment of Mild-to-Moderate Onychomycosis: A Randomized, Double-Blind Amorolfine Controlled Study Using a Blinded Evaluator.
This was a randomized, controlled, parallel-group clinical trial with a blinded evaluator, designed to compare the efficacy and safety of the nail lacquer P-3051 with amorolfine 5% in the treatment of mild-to-moderate toenail onychomycosis. Patients were treated for 48 weeks with P-3051 daily, or twice weekly with amorolfine 5%. Out of 120 evaluable patients, 60 (50.0%) received P-3051 and 60 (...
متن کاملCiclopirox HPCH Nail Lacquer after Failure of Topical Treatment with Amorolfine
According to a recent controlled study, about 85% of patients with onychomycosis fail to respond to a standard treatment with amorolfine 5%. An 8% ciclopirox nail hydrolacquer, based on hydroxypropyl chitosan technology (P-3051), has been shown to improve efficacy in topical treatment of onychomycosis. No comparative studies between P-3051 and amorolfine were hitherto published. It has been inv...
متن کاملCiclopirox nail lacquer 8% for the treatment of onychomycosis: a Canadian perspective.
Onychomycosis is prevalent in the Canadian population, and risk factors, such as old age and diabetes, are increasing. This condition has traditionally been treated using oral antifungal agents with varying degrees of success. Recently, ciclopirox nail lacquer 8% solution became the first topical agent approved in Canada for onychomycosis. Ciclopirox nail lacquer may be safe and effective for t...
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Amorolfine 5% and ciclopirox 8% nail lacquers are commonly used in topical treatment of onychomycosis. These formulations may be used alone or in combination with oral antifungal agents. Amorolfine and ciclopirox are valuable therapeutic options, however, their usage in monotherapy should be limited. Proper amorolfine and ciclopirox penetration through the nail plate is provided by transungual ...
متن کاملRandomized controlled trial of a water-soluble nail lacquer based on hydroxypropyl-chitosan (HPCH), in the management of nail psoriasis
BACKGROUND Nail psoriasis occurs in up to 50% of patients affected by psoriasis, with a significant impact on quality of life that leads to a real clinical need for new therapeutic options. AIM To confirm whether the strengthening and hardening properties of the hydroxypropyl-chitosan (HPCH) nail lacquer could improve the structure of the nail plates on psoriatic nails. MATERIALS AND METHOD...
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ژورنال
عنوان ژورنال: Skin Appendage Disorders
سال: 2015
ISSN: 2296-9195,2296-9160
DOI: 10.1159/000441569